Category: 954220-98-5

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 954220-98-5, name is 2,4-Dichloro-5-fluoro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 954220-98-5

Step 2 To 28 (25 g, 138 mmol) in THF (250 mL) at 0 C was added 30 g of a 25%/wt NaO e in methanol solution (138 mmol). Allowed to warm to room temperature over 30 minutes. Concentrated the reaction in vacuo. Purified the residue by silica gel chromatography (0-20% acetone/hexane over 20 minutes) to provide 29 (12. 6 g, 52%).

With the rapid development of chemical substances, we look forward to future research findings about 954220-98-5.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STAMFORD, Andrew, W.; GILBERT, Eric, J.; CUMMING, Jared, N.; WO2012/138590; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 954220-98-5 , The common heterocyclic compound, 954220-98-5, name is 2,4-Dichloro-5-fluoro-6-methylpyrimidine, molecular formula is C5H3Cl2FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 1b (0.130 g, 0.718 mmol), compound Int-1 (0.204 g, 0.718 mmol)And DIPEA (0.401 g, 2.730 mmol) were sequentially added to tetrahydrofuran (30 mL)And absolute ethanol (2 mL), heated to reflux and stirred for 12 h. Quench with water,Extract twice with ethyl acetate (30 mL), combine the ethyl acetate layers,It was washed with saturated brine (30 mL), dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure.Silica gel column chromatography (PE / EA = 20/1 to 10/1) was purified to obtain 0.115 g of pale yellow oil,That is, compound 1c.

The synthetic route of 954220-98-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yinxingshu Pharmaceutical (Suzhou) Co., Ltd.; Chen Li; Shao Qing; Gan Libin; (22 pag.)CN110590768; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.954220-98-5, name is 2,4-Dichloro-5-fluoro-6-methylpyrimidine, molecular formula is C5H3Cl2FN2, molecular weight is 181, as common compound, the synthetic route is as follows.Formula: C5H3Cl2FN2

Preparation of compound 8: compound 6 (0.62 g, 3.43 mmol), 7 (0.67 g, 3.43 mmol 1) and triethylamine (1.14 g, 13.02 mmol) were dissolved in a mixed solvent of 15 mL of tetrahydrofuran and 0.8 mL of ethanol, and heated under reflux for 5 hours.After the reaction is finished, spin dry,The crude product was subjected to column chromatography to give 0.46 g of Compound 8. Yield: 32.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,954220-98-5, 2,4-Dichloro-5-fluoro-6-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Yinxingshu Pharmaceutical (Suzhou) Co., Ltd.; Chen Li; Shao Qing; Jiang Tao; Wu Jin; (20 pag.)CN109384783; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia