Category: 956034-07-4

Adding a certain compound to certain chemical reactions, such as: 956034-07-4, 2,4-Dichlorofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,4-Dichlorofuro[3,2-d]pyrimidine, blongs to pyrimidines compound. Safety of 2,4-Dichlorofuro[3,2-d]pyrimidine

Step C: 2-Chloro-/V-(2,2,2-trifluoroethyl)furo[3,2-i/|pyrimidiTo a flask was added 2,4-dichlorofuro[3,2-i/]pyrimidine (0.80 g, 4.23 mmol, ArkPharm) and DMF (3.0 mL). 2,2,2-Trifluoroethanamine (1.05 g, 10.58 mmol, Acros) was added. The mixture was heated in a microwave at about 120 C for about 15 min. The mixture was diluted with Et20 (100 mL). The mixture was washed with water (3 x 25 mL). The combined aqueous layer was extracted with Et20 (2 x 50 mL). The combined organic layers were dried over Na2S04, filtered, and concentrated in vacuo. The residue was transferred neat and was purified by preparative TLC eluting with 3 :1 hexanes/EtOAc to give 2-chloro-A^-(2,2,2-trifluoroethyl)furo[3,2-i/]pyrimidin-4- amine (0.76 g, 71%): LC/MS (Table 2, Method h) Rt = 1.85 min; MS mix: 252, 254 (M+H)+.

The synthetic route of 956034-07-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; CALDERWOOD, David, J.; WILSON, Noel, S.; COX, Philip; HOEMANN, Michael, Z.; CLAPHAM, Bruce; MULLEN, Kelly, D.; VASUDEVAN, Anil; VILLAMIL, Clara I; LI, Bin; SOMAL, Gagandeep; WO2012/48222; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 956034-07-4, 2,4-Dichlorofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 956034-07-4, blongs to pyrimidines compound. Quality Control of 2,4-Dichlorofuro[3,2-d]pyrimidine

[0174] To a reaction flask were added compound 31-c (0.088 mmol), compound 31-b (according to the synthesisprocedure in the patent: WO 2011/079230 A2) (15 mg, 0.080 mmol), PdCl2(dppf) (3 mg, 0.004 mmol), 2 N aqueoussodium carbonate solution (0.12 mL, 0.24 mmol) and 1,4-dioxane (3 mL). Under nitrogen, the mixture was stirredovernight at 80C. After the reaction mixture was concentrated, the residue was diluted with water (15 mL), and theaqueous phase was extracted with dichloromethane (15 mL 3 2). The organic layers were combined and washedsuccessively with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to givecrude product 31-a (35 mg) which was used directly in the next reaction without further purification. LC-MS (ESI): m/z=248.1 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,956034-07-4, its application will become more common.

Reference:
Patent; Shanghai Yingli Science and Technology Co., Ltd; Shanghai Chemexplorer Co., Ltd.; XU, Zusheng; EP2860181; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below., category: pyrimidines

2,4-Dichlorofuro[3,2-d]pyrimidine 37 (23 mg, 1.0 eq) was suspended in methanol (1.7 ml) and treated with morpholine (0.09 ml, 4.0 eq). Reaction mixture was stirred at room temperature for 2 h, before being quenched with saturated aq. NaHCO3. Mixture was extracted with dichloromethane. The combined organic layers were dried (Na2SO4) and concentrated to yield 2-chloro-4-morpholinofuro[3,2-d]pyrimidine 38 (14 mg, 48%) which was used in the next reaction without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 956034-07-4, 2,4-Dichlorofuro[3,2-d]pyrimidine.

Reference:
Patent; PIRAMED LIMITED; GENENTECH, INC.; BAYLISS, Tracy; CHUCKOWREE, Irina; FOLKES, Adrian; OXENFORD, Sally; WAN, Nan, Chi; CASTANEDO, Georgette; GOLDSMITH, Richard; GUNZNER, Janet; HEFFRON, Tim; MATHIEU, Simon; OLIVERO, Alan; STABEN, Steven; SUTHERLIN, Daniel, P.; ZHU, Bing-Yan; WO2008/70740; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,4-Dichlorofuro[3,2-d]pyrimidine

A mixture of(lr,4r)-4-morpholinocyclohexan-1-ol (0.53 g, 2.9 mmol, 1.1 eq) in 5.0 mL of THF was prepared and 60% NaH (0.56 g, 14 mmol, 5.3 eq) was added. The reaction mixture was stirred at room temperature for 30 mm and 2,4-dichlorofuro[3,2-djpyrimidine (0.50 g, 2.6 mmol, 1.0 eq) was added and the resulting mixture was heated at 60 C for 3 hr. The reaction was cooled to room temperature and quenched with saturated aqueous ammonium chloride. The quenched mixture was rotary evaporated and purified on normal phase Combi-Flash using a 40 g column and eluting with a gradient of 0-20% MeOH/CH2C12 in 10 mm. The product containing fractions were combined and rotary evaporated to give 2-chloro-4-(((lr,4r)-4- morpholinocyclohexyl)oxy)furo[3,2-djpyrimidine (0.59 g, 1.7 mmol, 60% yield) as a white solid. LC-MS:M+H=338.0

With the rapid development of chemical substances, we look forward to future research findings about 956034-07-4.

Reference:
Patent; PHARMACYCLICS LLC; CHEN, Wei; JIA, Zhaozhong, J.; THOMAS, William, D.; WONE, David; (147 pag.)WO2017/205766; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 956034-07-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.

Preparation of 2-chloro-4-(3-nitrophenoxy -furo|”3.2- cnpyrimidine6.4 g (33.9 mmol) of 2,4-dichlorofuro[3,2-Patent; HANMI HOLDINGS CO. , LTD.; CHA, Mi Young; KANG, Seok Jong; KIM, Mi Ra; LEE, Ju Yeon; JEON, Ji Young; JO, Myoung Gi; KWAK, Eun Joo; LEE, Kwang Ok; HA, Tae Hee; SUH, Kwee Hyun; KIM, Maeng Sup; WO2011/162515; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 956034-07-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine, molecular formula is C6H2Cl2N2O, molecular weight is 188.9989, as common compound, the synthetic route is as follows.

Under nitrogen, to a suspension of compound 5-a (640 mg, 1.65 mmol), compound 30-c (280 mg, 1.49 mmol) and potassium carbonate (720 mg, 5.2 mmol) in 1,4-dioxane (2 mL) and water (6 mL) was added Pd(PPh3)4 (57 mg, 0.05 mmol), the mixture was heated to 80 C. and stirred for 16 hours. The mixture was then concentrated under reduced pressure, the residue was diluted with water (20 mL), extracted with dichloromethane (20 mL×3). The organic layer were combined, washed with water (10 mL×3) and saturated brine (10 mL) in sequence, then dried over anhydrous sodium sulfate, filtrated, the filtrate was concentrated under reduced pressure. The residue was purified by silica column chromatography (petroleum ether:ethyl acetate=3:1) to give light yellow solid 30-b (620 mg, yield: 70%). LC-MS (ESI): nm/z=415 [M+H]+.

Statistics shows that 956034-07-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichlorofuro[3,2-d]pyrimidine.

Reference:
Patent; SHANGHAI CHEMEXPLORER CO., LTD.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WANG, Tinghan; US2015/336982; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine, molecular formula is C6H2Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,4-Dichlorofuro[3,2-d]pyrimidine

Weigh 4-hydroxy-3,5-dimethylbenzonitrile (1.5 g, 10 mmol)And potassium carbonate (1.7 g, 12 mmol) in 30 mL of DMF,Stir at room temperature for 15 minutes.Then 2,4-dichlorofuro[3,2-d]pyrimidine 1 (1.9 g, 10 mmol) was addedStirring was continued for 2 h at room temperature (TLC detection was completed).Wait for a lot of white solids to form,Slowly add 100mL of ice water to it.filter,Vacuum drying,Recrystallization from ethanol gave Intermediate 5.White solid,Yield 96%,

With the rapid development of chemical substances, we look forward to future research findings about 956034-07-4.

Reference:
Patent; Shandong University; Liu Xinyong; Kang Dongwei; Zhan Peng; Fang Zengjun; Wang Zhao; (11 pag.)CN108586471; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine, molecular formula is C6H2Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2,4-Dichlorofuro[3,2-d]pyrimidine

Step A: 2-Chloro-/V-(2,2-difluoroethyl)furo[3,2-i/|pyrimidin-4-amineTo a flask was added 2,4-dichlorofuro[3,2-i/]pyrimidine (2 g, 10.58 mmol, Arkpharm), DCM (20 mL) and TEA (2.95 mL, 21.16 mmol). A solution of 2,2-difluoroethanamine (0.858 g, 10.6 mmol, Matrix) in DCM (5 mL) was added drop-wise and the mixture was stirred at rt overnight. The mixture was concentrated under reduced pressure. To the residue was added 1,4-dioxane (20 mL), TEA (2.95 mL, 21.2 mmol) and a solution of 2,2-difluoroethanamine (0.858 g, 10.58 mmol, Matrix) in 1,4-dioxane (5 mL). The mixture was stirred at rt for about 4 h, and then at about about 55 C overnight. The mixture was concentrated under reduced pressure, and the residue was taken up in EtOAc (120 mL) and water (25 mL). The organic layer was isolated and washed with water (2 x 25 mL). The combined aqueous layers were washed with EtOAc (2 x 25 mL). The combined organic layers were washed with brine (25 mL), dried with MgS04, filtered, concentrated under reduced pressure, and dried in a vacuum oven at about 70 C over 2 days to give 2-chloro-^-(2,2-difluoroethyl)furo[3,2-i/]pyrimidin-4-amine (2.20 g, 89 %): LC/MS (Table 2, Method c) R, = 1.69 min.; MS m/z: 234 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 956034-07-4.

Reference:
Patent; ABBOTT LABORATORIES; CALDERWOOD, David, J.; WILSON, Noel, S.; COX, Philip; HOEMANN, Michael, Z.; CLAPHAM, Bruce; MULLEN, Kelly, D.; VASUDEVAN, Anil; VILLAMIL, Clara I; LI, Bin; SOMAL, Gagandeep; WO2012/48222; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia