Reference of 96548-91-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96548-91-3, name is 2-Fluoropyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2-fluoropyrimidin-4-amine (1.94 g, 17.1 mmol), ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate (3.0 g, 11.4 mmol) and cesium carbonate (5.57 g, 17.1 mmol, Aldrich) was heated to 85 C. for 18 h. The mixture was cooled to RT, diluted with H2O and extracted with CH2Cl2 (2*) and CHCl3 (2*). The combined organics were dried over Na2SO4, Filtered and concentrated. Purifications by flash chromatography (0?15?50% EtOAc/Hexanes) afforded the title product. MS m/z 340 (MH)+.
According to the analysis of related databases, 96548-91-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Andersen, Denise Lyn; Chang, Catherine H.; Falsey, James R.; Frohn, Michael J.; Hong, Fang-Tsao; Liao, Hongyu; Liu, Longbin; Lopez, Patricia; Retz, Daniel Martin; Rishton, Gilbert M.; Rzasa, Robert M.; Siegmund, Aaron; Tadesse, Seifu; Tamayo, Nuria; Tegley, Christopher M.; US2006/69110; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
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