Reference of 96833-41-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96833-41-9, name is 2-Chloro-4-methoxypyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.
In a Shlenck reactor, a solution of 6-chloro-2-methoxy-3-nitropyridine (1.00 g, 5.30mmol), 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester (1.23 g, 5.83 mmol) andK3P04 (3.38 g, 15.90 mmol) in 1,4-dioxane (44 mL) and distilled water (9 mL) was degassed under N2. [1,1 ?-bis(diphenylphosphino)ferrocene] dichloropalladium (II), complex with dichloromethane (434.00 mg, 0.53 mmol) was added, the mixture was degassed again under N2 and heated at 80 C for 4 h. The mixture was extended withEtOAc and filtered on a pad of celite. The cake was washed with EtOAc and water. The layers were separated and the organic layer was dried over Mg504, filtered off and evaporated in vacuo to give a brown solid. The residue was purified by column chromatography on silica gel (irregular SiOH, 15-40 jim, 50 g, dry loading on celite, mobile phase: heptane/EtOAc, gradient: 95:5 to 60:40) to give 922 mg of intermediate138 (74% yield, yellow solid).
According to the analysis of related databases, 96833-41-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (476 pag.)WO2017/125534; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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