Category: 98138-75-1

Adding a certain compound to certain chemical reactions, such as: 98138-75-1, 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine, blongs to pyrimidines compound. name: 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine

To a solution of 6-chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine (100 mg, 0.54 mmol) in sec-BuOH (5 mL) was added (4-amino-3-methoxyphenyl)(morpholino)methanone (154 mg, 0.65 mmol) and K2C03 (150 mg, 1.08 mmol). The reaction mixture was degassed for 5 mm and then Pd2(dba)3 (30 mg, 0.032 mmol) and 2-dicyclohexylphosphino-2?,4?,6?- triisopropylbiphenyl (23 mg, 0.049 mmol) were added. The reaction flask was stirred at 110 C for 8 hr. After cooling to room temperature, the reaction mixture was filtered through a pad of celite and partitioned between ethyl acetate and water. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated. Purification by HPLC gave the title compound 58 mg (28% yield) as a light-brown solid. ?H NIVIR 400 MHz (DMSO-d6) 13.31 (br, 1H), 8.39 (d, J= 4 Hz, 1H), 7.98 (d, J= 8 Hz, 1H), 7.01 (m, 2H), 4.05 (s, 3H), 3.98 (s, 3H), 2.46 (m, 8H),MSm/z:385.23 [M+ 1].

The synthetic route of 98138-75-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael, S.; HATCHER, John; CHOI, Hwan, Geun; (198 pag.)WO2016/130920; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98138-75-1, name is 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H5ClN4O

Step 2: To a solution of 6-chl oro-4-m ethoxy- li7-pyrazolo[3,4- (1227) 1.7 g, 9.2 mmol) in DMF (20 mL) was added NaH (552.6 mg, 13.8 mmol, 60% in mineral oil). After 10 min, SEM-C1 (2.3 g, 13.8 mmol, 2.5 mL) was added. The reaction mixture was stirred at 25 C for 1 hour under an atmosphere of nitrogen. The reaction mixture was concentrated under reduced pressure. The residue was diluted with water (30 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were washed with water (2 x 30 mL), dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure to give a residue, which was purified by column chromatography (5-20% EtO Ac/petroleum ether). The desired 6-chl oro-4-methoxy-l -((2-(tri methyl si lyl)ethoxy)methyl)- l H- pyrazolo[3,4-i/]pyrimidine (1.3 g, 45.0% yield) was obtained as a light pink solid along with major impurity 6-chl oro-4-methoxy-2-((2-(tri methyl si lyl)ethoxy)methyl)-2//-pyrazolo[3, 4- i/]pyrimidine (520.0 mg, 17.9% yield), which was obtained as a light yellow solid.

The synthetic route of 98138-75-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; WALTERS, W., Patrick; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; TAYLOR, Alexander, M.; PIERCE, Levi Charles, Thomas; MURCKO, Mark, Andrew; GIORDANETTO, Fabrizio; GREISMAN, Jack, Benjamin; MARAGAKIS, Paul; BHAT, Sathesh; KONZE, Kyle; DAHLGREN, Markus, Kristofer; THERRIEN, Eric; (0 pag.)WO2019/165073; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 98138-75-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 98138-75-1 as follows.

To 6-chloro-4-methoxy-1 H-pyrazolo[3,4-d]pyrimidine (2.45 g) dissolved in dry DMF (60 ml) was added N-iodosuccinimide (3.45 g) and the reaction mixture heated to 80C under stirring. After 3 h the reaction mixture was cooled to RT and the DMF removed by rotary evaporation. Water was added to the residue which was then extracted three times with tert-butyl methyl ether. The combined organic phases were washed with water and brine and dried over sodium sulfate, filtered and evaporated to afford 6-chloro-3-iodo-4-methoxy-1 H-pyrazolo[3,4-d]pyrinnidine as a brown solid. Yield: 4.13 g (100%). MS (ES+): m/e = 310.9 (M+H), chloro pattern

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98138-75-1, its application will become more common.

Reference:
Patent; SANOFI; NAZARE, Marc; HALLAND, Nis; SCHMIDT, Friedemann; KLEEMANN, Heinz-Werner; WEISS, Tilo; SAAS, Joachim; STRUEBING, Carsten; WO2014/140065; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia