Reference of 98141-42-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98141-42-5, name is 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H4Cl2N4, molecular weight is 203.03, as common compound, the synthetic route is as follows.
Experimental for the Preparation of 1-Substituted-4-phenoxy-6-aryl-1H-pyrazolo[3,4-d]pyrimidine (Scheme 5)To a solution of the dichloride (2.53 mmol) dissolved in DMSO (5 mL) was added by drops a solution of phenol (0.7 eq) and NaH (0.7 eq) that had stirred for 30 minutes. The reaction mixture was stirred for 5 hr at room temperature and then used as a DMSO solution for the next step. To the portion of the product used (0.25 mmol) was added with the desired aryl boronic acid (1.5 eq), Na2CO3 solution (2 eq), and Pd(PPh3)4 (catalytic amount). The reaction heated at 150 C. for 16 hrs. The crude reaction then filtered purified via preparatory HPLC using a Gilson instrument.
The chemical industry reduces the impact on the environment during synthesis 98141-42-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Wyeth; US2010/15141; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia