Category: 99844-02-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99844-02-7, name is 4-(4-Methoxyphenyl)pyrimidin-2-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 4-(4-Methoxyphenyl)pyrimidin-2-amine

General procedure: The pyrimidine amine 3a-i (1.1 mmol), CuI (1.0 mmol) andanhydrous Cs2CO3 (2.0 mmol) were added to a round bottom flaskalong with magnetic stir bar and closed well with a septum. Theflask was evacuated and back filled with nitrogen gas three times.Dioxane (15 mL), 1-(5-bromo-1H-indol-3-yl)-2-(piperidin-1-yl)ethane-1,2-dione (6) (1.0 mmol) and DMEDA (1.0 mmol) wereadded by syringe at room temperature. The reaction mixture wasstirred at 80 C for 20 h under nitrogen atmosphere and then cooledto room temperature. Concentrated ammonia (4 mL) was added,and the mixture was extracted with ethyl acetate (3 x 20 mL). Thecombined organic layer was concentrated in vacuo, and the residuewas purified by column chromatography on silica gel.

The synthetic route of 99844-02-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guggilapu, Sravanthi Devi; Lalita, Guntuku; Reddy, T. Srinivasa; Prajapti, Santosh Kumar; Nagarsenkar, Atulya; Ramu, Shymala; Brahma, Uma Rani; Lakshmi, Uppa Jaya; Vegi, Ganga Modi Naidu; Bhargava, Suresh K.; Babu, Bathini Nagendra; European Journal of Medicinal Chemistry; vol. 128; (2017); p. 1 – 12;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99844-02-7, name is 4-(4-Methoxyphenyl)pyrimidin-2-amine, the common compound, a new synthetic route is introduced below. name: 4-(4-Methoxyphenyl)pyrimidin-2-amine

Sodium t-butoxide is added to a stirred suspension of anilino-pyrimidines, substituted sulfones, tris(dibenzylideneacetone)dipalladium(0), and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl in dioxane. The mixture is heated at 80 C. for 72 hours. The reaction is cooled to room temperature, and the mixture is filtered and washed with THF and MeOH. The solvent is removed by evaporation, and the residue is purified by pre-plate with EtOAc/MeOH (10:1.5).

The synthetic route of 99844-02-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wyeth; US2006/79543; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia