Category: 99979-77-8

Reference of 99979-77-8 ,Some common heterocyclic compound, 99979-77-8, molecular formula is C5H6ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1Preparation of Ethyl [(2-chloro-5-methoxypyrimidin-4-yl)amino]-carbonothioylcarbamate (2) 2-Chloro-5-methoxypyrimidin-4-amine (1) (6.4 g, 0.040 mol) was suspended in ethyl acetate (100 mL) and heated to near reflux. Ethyl isothiocyanatidocarbonate (8.9 g, 1.7 eq) was added all at once, and the mixture was maintained at reflux for 10 hours. The resulting slurry was cooled to 15° C., and the solid product was isolated by filtration and the cake washed with fresh ethyl acetate to afford the title compound in several crops as a solid (7.8 g, 67percent): mp 182° C.; 1H NMR (DMSO-d6): delta 11.97 (s, 1H), 11.72 (s, 1H), 8.50 (s, 1H), 4.22 (q, 2H), 3.72 (s, 3H), 1.17 (t, 3H); 13C NMR (DMSO-d6): delta 177.82, 153.58, 150.00, 149.01, 144.26, 142.63, 62.76, 57.56, 14.44; Mass spec (accurate mass): Calcd for C9H11ClN4O3S: 290.024039; found, 290.0241.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 99979-77-8, 2-Chloro-5-methoxypyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOW AGROSCIENCES LLC; US2011/295003; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99979-77-8, name is 2-Chloro-5-methoxypyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-methoxypyrimidin-4-amine

Synthesis of 4-amino-2-chloropyrimidin-5-ol [0346] To a stirred solution of 2-chloro-5-methoxypyrimidin-4-amine (5 g, 31.44 mmol) in CH2CI2 (750 mL) under argon atmosphere at 0 °C was added BBr3 (45.5 mL, 471.69 mmol) drop-wise. The reaction was allowed to warm to RT and stirred for 32 h. After completion of the reaction (monitored by TLC), the reaction was quenched with methanol (22.5 mL) and stirred for lh. The suspension was filtered and the resultant solid dried in vacuo to afford 4-amino-2-chloropyrimidin-5-ol (4.5 g) as a brown solid and used without further purification. 1H-NMR (DMSO-< 5, 500 MHz): delta 10.04 (brs, 1H), 7.48 (s, 1H); LC- MS: 146.2 (M+l); (column; Eclipse XDB C-18 (150 4.6 mm, 5 mupiiota); RT 3.37 min. 0.05percent Aq TFA: ACN; 1.0 ml/min); TLC: 60percent EtOAc:hexanes (R/. 0.5). If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 99979-77-8, 2-Chloro-5-methoxypyrimidin-4-amine. Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 99979-77-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.99979-77-8, name is 2-Chloro-5-methoxypyrimidin-4-amine, molecular formula is C5H6ClN3O, molecular weight is 159.57, as common compound, the synthetic route is as follows.

30 mg 2-chloro-5-methoxypyrimidin-4-amine (0.19 mmol, 1.0 eq.), 55 mg 4-bromo-pyridine hydrochloride (1:1) (282 pmol, 1.5 eq.), 54 mg sodium tert-butoxide (0.56 mmol, 3.0 eq.), 2.1 mg palladium(ll)acetate (0.009 mmol, 0.05 eq.) and 8.2 mg 2,2- bis(diphenylphosphino)-1,1-binaphthyl (0.013 mmol) were suspended in 0.6 mL dioxane. The mixture was stirred at 90 C over night. 27 mg 4-bromopyridine hydrochloride (1:1) (141 pmol, 0.75 eq.), 27 mg sodium tert-butoxide (0.28 mmol, 1.5eq.), 1.1 mg palladium(ll)acetate (0.005 mmol, 0.025 eq.) and 4.1 mg 2,2- bis(diphenylphosphino)-1,1-binaphthyl (0.007 mmol) were added and the reaction mixture was stirred at 90 C for further 6 h. The reaction mixture was diluted with dichloromethane and filtered through celite. The filtrate was concentrated in vacuo. The crude product was purified by flash chromatography to provide the 72percent pure targetcomound: 13 mg, 0.05 mmol, 29percent.1HNMR (300MHz, DMSO-d6): 6 [ppm]= 3.94 (5, 3H), 7.82 (d, 2H), 8.07 (5, 1H), 8.41 (d,2H), 9.63 (5, 1 H).

The chemical industry reduces the impact on the environment during synthesis 99979-77-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HITCHCOCK, Marion; HILGER, Christoph-Stephan; MENGEL, Anne; BRIEM, Hans; SIEMEISTER, Gerhard; FERNANDEZ-MONTALVAN, Amaury, Ernesto; SCHROeDER, Jens; PREUSSE, Cornelia; (101 pag.)WO2017/148995; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia