Category: quinolines-derivatives

Adding a certain compound to certain chemical reactions, such as: 26892-90-0, name is Ethyl 4-hydroxyquinoline-3-carboxylate, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26892-90-0, Formula: C12H11NO3

WeighEthyl 4-hydroxy-2-hydro-quinoline-3-carboxylate(2.0 g) was dissolved in an appropriate amount of dioxane, then added with phosphorus oxychloride (0.68 mL), and then heated under reflux for 1 hour. After the reaction was completed, the reaction solution was poured into ice water and extracted with ethyl acetate (100 mL) The organic phase is combined, the organic phase is washed with brine, dried over anhydrous sodium sulfate(63% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-hydroxyquinoline-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 661463-17-8, name is 4-Bromo-6-fluoroquinoline, A new synthetic method of this compound is introduced below., Formula: C9H5BrFN

The compound 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester14a (1.64 g, 5.3 mmol), 4-bromo-6-fluoroquinoline (1 g, 4.4 mmol), tetrakis(triphenylphosphine)palladium (508 mg, 0.44 mmol), potassium carbonate (1.22 g, 8.8 mmol), water (2 ml) and 1,4-dioxane (10 ml) were mixed, and then heated in a microwave reactor at 110 C for 30 minutes under a nitrogen atmosphere. After cooling to room temperature, it was filtered, and the filtrate was evaporated under reduced pressure. To give the desired product 4-(6-fluoroquinolin-4-yl)-3,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester 14b (2g, crude).This product was used directly in the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33985-71-6, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde, A new synthetic method of this compound is introduced below., SDS of cas: 33985-71-6

General procedure: A mixture of an aromatic or heteroaromatic aldehyde(10.00 mmol) and an active methylene compound (10.0mmol) in acetic anhydride (15 mL) was stirred underexclusion of moisture in a water bath at 90C for 8 h.Under consumption of the starting material a deeply colouredsolution was observed and by the time a crystallineprecipitate was formed. After cooling to 0C the precipitatewas filtered off by suction, washed exhaustively withmethanol (100-200 mL) until the filtrate showed thecolour of the desired product in solution and then dried inair at room temperature.The following compounds were so prepared.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3747-74-8 as follows. Computed Properties of C10H9Cl2N

EXAMPLE 8 A mixture of 2-[1-hydroxy-1-(3-hydroxyphenyl)-2,2,2-trifluoroethyl]thiazole (0.33 g), 2-chloromethylquinoline hydrochloride (0.22 g), potassium carbonate (0.5 g) and dimethylformamlde (5 ml) was stirred at ambient temperature for Z4 hours. The mixture was partitioned between ethyl aceiate and water and the organic layer was separated, washed with a saturated aqueous sodium chloride solution, dried (MgSO4) and evaporated. The residue was purified by column chromatography eluding with chloroform/ethyl acetate (9/1 v/v) to give 2-[1-hydroxy-1-[3-(quinol-2-ylmethoxy)phenyl]-2,2,2-trifluoroethyl]thiazole (0.15 g, 30%), m.p. 177 C.

According to the analysis of related databases, 3747-74-8, the application of this compound in the production field has become more and more popular.

Related Products of 56826-69-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56826-69-8 as follows.

A 150 mL toluene solution of 5,6,7-trihydroquinolin-8-one (0.882 g, 5.99 mmol), 2-benzhydrylnaphthylamine (2.04 g, 6.59 mmol), and a catalytic amount of p-toluenesulfonic acid (0.228 g, 1.20 mmol) was refluxed for 8 h. The solvent was evaporated under reduced pressure, and then the mixture was purified by column chromatography on basic alumina with petroleum ether/ethyl acetate (v/v = 10:1) as eluent to afford the product as a yellow powder in 37% yield. Mp: 165-166 C. 1H NMR (400 MHz, CDCl3, TMS): deltaH 8.80 (d, 1H, 3JHH = 3.2 Hz, Py-H), 7.79 (d, 1H, 3JHH = 8.0 Hz, Py-H), 7.57 (d, 1H, 3JHH = 8.4 Hz, Py-H), 7.50 (d, 2H, 3JHH = 8.4 Hz, Ar-H), 7.41-7.08 (m, 14H, Ar-H), 5.92 (s, 1H, -CHPh2), 2.72-2.64 (m, 1H, -CH2), 2.53-2.46 (m, 1H, -CH2), 1.90-1.83 (m, 1H, -CH2), 1.20-1.13 (m, 1H, -CH2), 0.88-0.77 (m, 2H, -CH2). 13C NMR (100 MHz, CDCl3, TMS): 167.8, 149.8, 148.9, 146.2, 144.5, 142.9, 137.5, 137.2, 132.8, 130.2, 129.7, 128.6, 128.3, 128.1, 127.6, 126.1, 125.5, 125.0, 123.5, 122.5, 51.8, 31.4, 29.2, 21.2. FT-IR (KBr, disk, cm-1): 3054, 3026, 1641 (nuC=N), 1564, 1488, 1450, 1428, 1375, 1315, 1199, 1097, 1028, 790, 745, 701. Anal. Calc.d for C32H26N2 (438.21): C, 87.64; H, 5.98; N, 6.39%; Found: C, 87.48; H, 6.22; N, 6.27%.

According to the analysis of related databases, 56826-69-8, the application of this compound in the production field has become more and more popular.

Reference of 205448-66-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 205448-66-4, name is Methyl 4-chloro-7-methoxyquinoline-6-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

4.1) In a 500 mL three-necked flask in which ammonia (200 mL, 5.2 mol) is placed, the compound IV (10 g, 39.8 mmol) obtained in the step 3.3) is added to obtain a mixture H;4.2) The mixture H obtained in step 4.1) was placed at 60 C, after 4 h reaction, cooled to room temperature to obtain a mixture I;4.3) Adding dichloromethane to the mixture I and extracting three times to obtain a pale yellow compound V (yield 85.17%)

The chemical industry reduces the impact on the environment during synthesis Methyl 4-chloro-7-methoxyquinoline-6-carboxylate. I believe this compound will play a more active role in future production and life.

Application of 142569-70-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 142569-70-8, name is (S)-1-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Stage 2.A 250 mL three-necked flask fitted with a stirrer, thermometer and dropping funnel is flushed with nitrogen. 45 g (0.0983 mol) of 2-(2-(3(S)-(3-(2-(7-chloro-2- quinolinyl)-ethenyl)phenyl)-3-(hydroxypropyl)phenyl)-2-propanol and 120 mL of N,N-dimethylformamide is poured into the flask and stirred until the diol dissolves completely. The content is cooled to between -20 and -15C in the CO2/acetone bath. After cooling 15.7 mL (11.43 g; 0.1130 mol) of triethylamine is added, the temperature is maintained at -20 to -15C and 12.38 g (8.4 mL; 0.1081 mol) of methanesulfonyl chloride is added dropwise over 40 minutes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-1-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18704-37-5, name is Quinoline-8-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Quinoline-8-sulfonyl chloride

General procedure: Sulfonyl chloride 1 (0.2 mmol) was added into a solution of Na2SO3 (2.0 equiv) and NaHCO3 (2.0 equiv) in H2O (1.0 mL). The mixture was stirred at 80C for 4h. After evaporation of water, PhNHSCF3 2 (0.3 mmol), 4-methylbenzenesulfonic acid (0.5mmol) and DCE (2 ml) were added. The mixture was stirred at room temperature. After completion of the reaction as indicated by TLC, the reaction mixture was filtered by sand core funnel with silica gel and washed by CH2Cl2. The volatiles were removed and the residue was purified by flash column chromatography (SiO2) to provide the final products 3.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 18704-37-5.

Synthetic Route of 3747-74-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3747-74-8 as follows.

General procedure: To a mixture of 3-bromo-4-nitrophenol (26, 4.91 g, 22.5 mmol), 2-(chloromethyl)quinoline hydrochloride (5.79 g, 27.0 mmol) and potassium iodide (374 mg, 2.25 mmol) in DMF (50 mL) was added K2CO3 (7.47 g, 54.1 mmol), and the mixture was stirred at 60 C for 90 min. After cooling at room temperature, the mixture was diluted with EtOAc, and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was washed with EtOAc-hexane to give 27 (6.89 g, 85%) as a pale yellow solid.

According to the analysis of related databases, 3747-74-8, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 881-07-2, name is 2-Methyl-8-nitroquinoline, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 881-07-2, SDS of cas: 881-07-2

Example 7 Synthesis of 2-methyl-8-aminoquinoleine (Compound Y) Ziessel, R.; Weibel, N.; Charbonniere, L. S. Synthesis 2006, 18, 3128-3133 2.110 g of 8-nitroquinaldine (11.19 mmol) are dissolved in 34 mL HI (57% aq). The reaction mixture is heated to 90 C. for 2 h. At ambient temperature, the reaction medium is neutralized with 150 mL of a NaHCO3 saturated aqueous solution. The aqueous phase is extracted with AcOEt (3*50 mL). The combined organic phases are washed with a Na2S2O3 saturated aqueous solution (2*50 mL), then with brine (2*50 ml). The organic phases are dried on MgSO4, filtered and evaporated under vacuum. The raw product is purified using a flash chromatography column on silica (eluent: CH2Cl2 100%). 1.251 g of a beige solid is obtained. Yield: 89%. deltaH (300 MHz, CD2Cl2) 2.69 (s, 3H), 4.96 (bs, 2H, NH2), 6.88 (dd, 1H, J 7.4 and 1.3 Hz), 7.09 (dd, 1H, J 8.1 and 1.3 Hz), 7.25 (m, 2H), 7.96 (d, 1H, J 8.4 Hz); RMN 13C: deltaC (75 MHz, CD2Cl2) 25.0, 109.8, 115.6, 122.2, 126.4, 127.0, 136.0, 137.8, 143.7, 156.3 ppm; IR: 3467, 3385, 3343, 2365, 3048, 2917, 1616, 1595, 1563, 1507, 1475, 1431, 1373, 1344, 1323, 1284, 1274, 1243, 1137, 1080, 1032, 828, 794, 744, 715, 692 cm-1. SM: El m/z: 158, 131, 103.

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