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Krasnov, Victor P. published the artcileSynthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity, Application In Synthesis of 56-05-3, the publication is Molecules (2022), 27(13), 4236, database is CAplus and MEDLINE.

A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in various chloropyrimidines. Enantiomeric purity of optically active derivatives was confirmed by chiral HPLC. Antiviral evaluation of the synthesized compounds has shown that the replacement of purine with a pyrimidine fragment leads to a decrease in the anti-herpesvirus activity compared to the lead compound, purine conjugate. The studied compounds did not exhibit significant activity against influenza A (H1N1) virus.

Molecules published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Application In Synthesis of 56-05-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers was written by Zingg, Daniel;Bhin, Jinhyuk;Yemelyanenko, Julia;Kas, Sjors M.;Rolfs, Frank;Lutz, Catrin;Lee, Jessica K.;Klarenbeek, Sjoerd;Silverman, Ian M.;Annunziato, Stefano;Chan, Chang S.;Piersma, Sander R.;Eijkman, Timo;Badoux, Madelon;Gogola, Ewa;Siteur, Bjoern;Sprengers, Justin;de Klein, Bim;de Goeij-de Haas, Richard R.;Riedlinger, Gregory M.;Ke, Hua;Madison, Russell;Drenth, Anne Paulien;van der Burg, Eline;Schut, Eva;Henneman, Linda;van Miltenburg, Martine H.;Proost, Natalie;Zhen, Huiling;Wientjens, Ellen;de Bruijn, Roebi;de Ruiter, Julian R.;Boon, Ute;de Korte-Grimmerink, Renske;van Gerwen, Bastiaan;Feliz, Luis;Abou-Alfa, Ghassan K.;Ross, Jeffrey S.;van de Ven, Marieke;Rottenberg, Sven;Cuppen, Edwin;Chessex, Anne Vaslin;Ali, Siraj M.;Burn, Timothy C.;Jimenez, Connie R.;Ganesan, Shridar;Wessels, Lodewyk F. A.;Jonkers, Jos. And the article was included in Nature (London, United Kingdom) in 2022.Related Products of 219580-11-7 The following contents are mentioned in the article:

Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However, clin. responses to FGFR inhibitors have remained variable1-9, emphasizing the need to better understand which FGFR2 alterations are oncogenic and therapeutically targetable. Here we apply transposon-based screening10,11 and tumor modeling in mice12,13, and find that the truncation of exon 18 (E18) of Fgfr2 is a potent driver mutation. Human oncogenomic datasets revealed a diverse set of FGFR2 alterations, including rearrangements, E1-E17 partial amplifications, and E18 nonsense and frameshift mutations, each causing the transcription of E18-truncated FGFR2 (FGFR2ΔE18). Functional in vitro and in vivo examination of a compendium of FGFR2ΔE18 and full-length variants pinpointed FGFR2-E18 truncation as single-driver alteration in cancer. By contrast, the oncogenic competence of FGFR2 full-length amplifications depended on a distinct landscape of cooperating driver genes. This suggests that genomic alterations that generate stable FGFR2ΔE18 variants are actionable therapeutic targets, which we confirmed in preclin. mouse and human tumor models, and in a clin. trial. We propose that cancers containing any FGFR2 variant with a truncated E18 should be considered for FGFR-targeted therapies. This study involved multiple reactions and reactants, such as 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7Related Products of 219580-11-7).

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 219580-11-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wu, Wenneng published the artcileSynthesis and bioactivity study of novel pyridylpyrazolamide derivatives containing pyrimidine motifs, Computed Properties of 5472-46-8, the main research area is chloropyridinyl pyrazolecarboxamidopyrimidine preparation fungicide insecticide; amide; antifungal activity; insecticidal activity; pyridylpyrazol; pyrimidine.

In this study, thirteen new pyridylpyrazolamide derivatives containing pyrimidine motifs I (R1 = Cl, Br; R2 = COOMe, CONHMe, 5-methyl-1,2,4-oxadiazol-3-yl, etc.) were synthesized in six-step reactions. Bioassay results showed that some of the synthesized compounds revealed good antifungal properties against Sclerotinia sclerotiorum, Phytophthora infestans, Thanatephorus cucumeris, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Botryosphaeria dothidea, and Phomopsis sp. at 50μg/mL, which were similar to those of Kresoxim-Me or Pyrimethanil. Meanwhile, bioassay results indicated that the synthesized compounds showed a certain insecticidal activity against Spodoptera litura, Mythimna separata, Pyrausta nubilalis, Tetranychus urticae, Rhopalosiphum maidis, and Nilaparvata lugens at 200μg/mL, which was lower than that of Chlorantraniliprole. This study is the first report on the antifungal and insecticidal activities of pyridylpyrazolamide derivatives containing a pyrimidine moiety.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Agrochemical fungicides. 5472-46-8 belongs to class pyrimidines, name is Ethyl 4-amino-2-methylpyrimidine-5-carboxylate, and the molecular formula is C8H11N3O2, Computed Properties of 5472-46-8.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.

Siegrist, Romain;Pozzi, Davide;Jacob, Gael;Torrisi, Caterina;Colas, Kilian;Braibant, Bertrand;Mawet, Jacques;Pfeifer, Thomas;de Kanter, Ruben;Roch, Catherine;Kessler, Melanie;Moon, Richard;Corminboeuf, Olivier;Bezencon, Olivier research published 《 Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers [Erratum to document cited in CA166:161420]》, the research content is summarized as follows. Richard Moon has been added as a co-author; the new author order is provided here.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called New reagent for vitamin B6 derivative formation in gas chromatography, published in 1977, which mentions a compound: 148-51-6, Name is 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, Molecular C8H12ClNO2, Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.

Gas-chromatog. separation of 4 vitamin B6 derivatives consisted of converting them into hemiacetals with EtOH, refluxing at 125° for 15 min, evaporating the excess EtOH at 70° under N, and adding the new reagent N-methylbistrifluoroacetamide [685-27-8], followed by refluxing at 125° for 20 min and injecting the samples onto a column packed with 5% silicone oil on Chromosorb P and using flame ionization detection. The compounds derivatized were pyridoxine-HCl (I) [58-56-0], pyridoxamine-di-HCl [524-36-7], deoxypyridoxine-HCl [148-51-6] and pyridoxal-HCl [65-22-5]. The min. detectable amount is ∼250 ng. The procedure is rapid, clean, and simple.

Here is just a brief introduction to this compound(148-51-6)Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, more information about the compound(5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia