On September 25, 2014, Chan, Bryan; Estrada, Anthony; Shore, Daniel; Sweeney, Zachary published a patent.Formula: C8H10BrN3O The title of the patent was Preparation of pyrazolopyridine compounds as LRRK2 inhibitors. And the patent contained the following:
The invention relates to pyrazolopyridine compounds of formula I and II, or pharmaceutically acceptable salts thereof that are useful for the treatment of the diseases associated with LRRK2. Compounds of formula I and II wherein R1 is (un)substituted alkyl, heterocycloalkyl, cycloalkyl, etc.; for formula I, one, two, or three of X1-X4 are N and the remainder are each independently CR2; or X1-X4 are independently CR2; for formula II, X4 is C or N; and one or two of X1-X3 are independently N or NR8, and the remainder are each independently CR2; each R2 is independently H, alkyl, cyano, halo, heteroaryl, OR4, CONR5R6, SO2R7, etc.; each R8 is independently H or (un)substituted alkyl; R4-R7 are independently H or alkyl; R5 and R6 together with nitrogen to which they are attached are linked to form a ring; are claimed. Example compound III was prepared by cyclocondensation of compound IV with hydrazine hydrate, followed by deprotection in 25% yield over two steps. The invention compounds were evaluated for the LRRK2 inhibitory activity and compound III shows 0.0005 μM of Ki. The experimental process involved the reaction of 4-(2-Bromopyrimidin-4-yl)morpholine(cas: 1209459-32-4).Formula: C8H10BrN3O
The Article related to pyrazolopyridine preparation lrrk2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C8H10BrN3O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia