Chang, Lisa C. W. et al. published their research in Journal of Medicinal Chemistry in 2004 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine

2,4,6-Trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists was written by Chang, Lisa C. W.;Spanjersberg, Ronald F.;von Kuenzel, Jacobien K.;Mulder-Krieger, Thea;van den Hout, Gijs;Beukers, Margot W.;Brussee, Johannes;Ijzerman, Adriaan P.. And the article was included in Journal of Medicinal Chemistry in 2004.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Adenosine receptor antagonists usually possess a bi- or tricyclic heteroaromatic structure at their core with varying substitution patterns to achieve selectivity and/or greater affinity. Taking into account mol. modeling results from a series of potent adenosine A1 receptor antagonists, a pharmacophore was derived from which a monocyclic core can be equally effective. To achieve a compound that may act at the CNS, a restriction related to its polar surface area (PSA) was proposed. In consequence, two series of pyrimidines, e.g., I, possessing good potency at the adenosine A1 receptor and desirable PSA values were synthesized. In particular, I (LUF 5735) displayed excellent A1 affinity (Ki = 4 nM) and selectivity (≤50% displacement of 1 μM concentrations of the radioligand at the other three adenosine receptors) and has a PSA value of 53 Å2. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia