Chantell, Christina A.’s team published research in American Biotechnology Laboratory in 27 | CAS: 186046-81-1

American Biotechnology Laboratory published new progress about 186046-81-1. 186046-81-1 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C39H35N5O8, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid.

Chantell, Christina A. published the artcileLow-cost, automated synthesis of a PNA-peptide conjugate on a peptide synthesizer, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid, the publication is American Biotechnology Laboratory (2009), 27(8), 8-10, database is CAplus.

Two peptide nucleic acid (PNA) sequences, one containing a lysine residue at the C-terminus and the other containing a peptide analog of LH-releasing hormone, were synthesized in an automated peptide synthesizer. The PNA sequence was constructed from protected monomers, Fmoc-A(Bhoc)aeg-OH, Fmoc-C(Bhoc)aeg-OH, Fmoc-G(Bhoc)aeg-OH and Fmoc-T-aeg-OH, which were coupled to Fmoc-Lys(Boc)-Wang resin using HATU as a coupling reagent. This work demonstrated the successful automated synthesis of a PNA sequence and a PNA-peptide conjugate on “Prelude” automated peptide synthesizer which enabled minimizing overall consumption and costs.

American Biotechnology Laboratory published new progress about 186046-81-1. 186046-81-1 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C39H35N5O8, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia