《Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors》 was published in Beilstein Journal of Organic Chemistry in 2012. These research results belong to Che, Chao; Li, Song; Yang, Bo; Xin, Shengchang; Yu, Zhixiong; Shao, Taofeng; Tao, Chuanye; Lin, Shuo; Yang, Zhen. Application In Synthesis of 3-(Pyrimidin-5-yl)benzaldehyde The article mentions the following:
The previously described 3-chloro-N-[trans-4-(propylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide [Sant-75] (I) is a newly identified potent inhibitor of the Hedgehog pathway [Smo receptor (Smoothened) antagonist]. The authors designed a diversity-oriented synthesis program and the synthesis of the target compounds (series of Sant-75 analogs) was achieved, which lays a foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors. The results came from multiple reactions, including the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Application In Synthesis of 3-(Pyrimidin-5-yl)benzaldehyde)
3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Application In Synthesis of 3-(Pyrimidin-5-yl)benzaldehyde
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia