Chekler, Eugene L. Piatnitski et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 171096-33-6

Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C7H6Cl2N2O2

1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators was written by Chekler, Eugene L. Piatnitski;Unwalla, Rayomond;Khan, Taukeer A.;Tangirala, Raghuram S.;Johnson, Mark;St. Andre, Michael;Anderson, James T.;Kenney, Thomas;Chiparri, Sue;McNally, Chris;Kilbourne, Edward;Thompson, Catherine;Nagpal, Sunil;Weber, Gregory;Schelling, Scott;Owens, Jane;Morris, Carl A.;Powell, Dennis;Verhoest, Patrick R.;Gilbert, Adam M.. And the article was included in Journal of Medicinal Chemistry in 2014.Computed Properties of C7H6Cl2N2O2 This article mentions the following:

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biol. activity and phys. properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramol. interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating LH (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicol. study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days. In the experiment, the researchers used many compounds, for example, Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6Computed Properties of C7H6Cl2N2O2).

Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C7H6Cl2N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia