The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-Methoxypyrrolidine( cas:120099-61-8 ) is researched.Recommanded Product: 120099-61-8.Sun, Chang’an; Fang, Lei; Zhang, Xiaobing; Gao, Peng; Gou, Shaohua published the article 《Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies》 about this compound( cas:120099-61-8 ) in Bioorganic & Medicinal Chemistry. Keywords: antitumor FGFR4 selectivity pharmacokinetic profile; Antitumor; FGFR4; Pharmacokinetic profile; Selectivity. Let’s learn more about this compound (cas:120099-61-8).
Total twenty-five 7-formyl-naphthyridyl-urea derivatives were designed, synthesized and evaluated for their inhibition of FGFR4 kinase and antitumor activity. The pharmacol. data indicated that most of the tested compounds showed high selectivity towards FGFR4 kinase and could significantly inhibit FGFR4 and the tumor cells lines with the high expression of FGFR4. In particular, compounds 6f, 6g, 6h, 6l, 6m and 6s showed a good performance in pharmacokinetic tests. When tested in mice, the representative compound 6f was found to have good pharmacokinetic parameters, low toxicity, and better tumor inhibiting activity in vivo.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia