On August 10, 2017, Chen, Gang; Chrovian, Christa C.; Coate, Heather R.; Dvorak, Curt A.; Gelin, Christine F.; Hiscox, Afton; Letavic, Michael A.; Rech, Jason C.; Soyode-Johnson, Akinola; Stenne, Brice; Wall, Jessica L.; Zhang, Wei published a patent.Recommanded Product: 596114-50-0 The title of the patent was Preparation of substituted 1,2,3-triazoles as NR2B-selective NMDA modulators. And the patent contained the following:
The invention relates to substituted 1,2,3-triazoles of formula I as NR2B receptor ligands that may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by NR2B receptor activity. Compounds of formula I, wherein Ar1 is substituted Ph, (un)substituted pyridyl, substituted thienyl; R1 is H, halo, Me; R2 is H and Me; Ar3 is (un)substituted pyridyl, (un)substituted pyridazinyl, (un)substituted pyrimidin-4-yl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by condensation of (1-(4-chloro-3-(difluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol with 2-chloropyrimidine. The invention compounds were evaluated for their NR2B modulatory activities. From the assay, it was determined that compound II exhibited IC50 value of 0.049 μM. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Recommanded Product: 596114-50-0
The Article related to preparation substituted triazole nr2b selective nmda modulator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 596114-50-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia