Cheng, Yuan published the artcileSupramolecular structures constructed by 3-(2-amino-6-chloropyrimidin-4-yl)-1,1-dimethylprop-2-yn-1-ol monohydrate and 3-[2-amino-6-(3-hydroxy-3,3-dimethylprop-1-yn-1-yl)pyrimidin-4-yl]-1,1-dimethylprop-2-yn-1-ol, Safety of 2-Amino-4,6-dichloropyrimidine, the publication is Acta Crystallographica, Section C: Crystal Structure Communications (2011), 67(7), o244-o248, database is CAplus and MEDLINE.
The mol. of 3-(2-amino-6-chloropyrimidin-4-yl)-1,1-dimethylprop-2-yn-1-ol monohydrate, C9H10ClN3O·H2O, (I), shows a very polarized mol.-electronic structure, while the polarization is slight for 3-[2-amino-6-(3-hydroxy-3,3-dimethylprop-1-yn-1-yl)pyrimidin-4-yl]-1,1-dimethylprop-2-yn-1-ol, C14H17N3O2, (II). In the supramol. structure of (I), a combination of hard N-H…N H bonds and soft C-H…N H bonds creates a mol. column. Aromatic π-π stackings between the pyrimidine rings stabilize the column with perpendicular and centroid-centroid distances of 3.283(3) and 3.588(1) Å, resp. Short Cl…Cl contacts further link neighboring mol. columns, creating a hydrophilic tube in which H2O mols. are fixed by various H bonds. In the packing of (II), a 1-dimensional mol. chain is formed through several contacts involving hard N-H…O(N) and O-H…O(N) and soft C-H…O H bonds. Interchain O-H…O H bonds link the chains giving a two-dimensional stepped network. It is anticipated that study of the influence of H bonding on the patterns of base pairing and mol. packing in aminopyrimidine structures will shed significant light on nucleic acid structures as well as their functions. Crystallog. data are given.
Acta Crystallographica, Section C: Crystal Structure Communications published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Safety of 2-Amino-4,6-dichloropyrimidine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia