Cheng, Zhiwen et al. published their research in Journal of Hazardous Materials in 2022 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C11H12N4O3S

The investigation of influencing factors on the degradation of sulfonamide antibiotics in iron-impregnated biochar-activated urea-hydrogen peroxide system: A QSAR study was written by Cheng, Zhiwen;Chen, Qincheng;Liu, Shiqiang;Liu, Yawei;Ren, Yuanyang;Zhang, Xuxiang;Shen, Zhemin. And the article was included in Journal of Hazardous Materials in 2022.Formula: C11H12N4O3S This article mentions the following:

Iron-impregnated biochar-activated urea-hydrogen peroxide (FB-activated UHP) is a potential in-situ technol. for simultaneously reducing soil sulfonamide antibiotic contaminants and improving soil fertility. To better understand the degradation of sulfonamide antibiotics by FB-activated UHP, a two-dimensional quant. structure-activity relationship (2D-QSAR) model based on quantum chem. parameters and a three-dimensional QSAR (3D-QSAR) model based on mol. force field were developed to investigate the factors influencing the removal efficiencies (Re%). The optimal 2D-QSAR model was Re%= 0.858-8.930 E-5 EB3LYP-0.175 f(+)x with the evaluation indexes of R2= 0.732, q2= 0.571, and Q2ext= 0.673. The given 2D-QSAR model indicated that the mol. size (EB3LYP) and Fukui index with respect to nucleophilic attack (f( + )) were intrinsic factors influencing Re%. Three degradation pathways were subsequently proposed based on the f( + ) distribution. Compared to the 2D-QSAR model, the developed 3D-QSAR model exhibited a better predictive ability, with the evaluation indexes of R2= 0.989, q2= 0.696, and SEE= 0.001. The anal. of field contribution rates suggested that electrostatic field (48.2%), hydrophobic field (25.3%), and hydrogen-bond acceptor field (12.7%) were the main factors influencing Re%. These findings generated critical information for evaluating the degradation mechanisms/rules and provided theor. bases for initially estimating the Re% of sulfonamide antibiotics undergoing FB-activated UHP process. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia