On September 18, 2014, Chesworth, Richard; Moradei, Oscar Miguel; Shapiro, Gideon; Jin, Lei; Babine, Robert E. published a patent.Name: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride The title of the patent was 1-Amino-3-(aryloxy)propanol derivatives as CARM1 inhibitors and uses thereof. And the patent contained the following:
Provided herein are compounds of formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; and their use for inhibiting CARM1 activity and for treating CARM1-mediated disorders. Compounds of formula I wherein X is O, S and CH2; R1 is H and (un)substituted C1-4 alkyl; R1a is H; each R2 are independently H, halo, CN, NO2, acyl, etc.; HET is 6-membered monocyclic nitrogen-containing heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their CARM1 inhibitory activity (data given). The experimental process involved the reaction of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride(cas: 1187830-46-1).Name: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride
The Article related to amino aryloxypropanol preparation carm1 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia