The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis was written by Cheung, Shilin; Ly, Jimmy; Lazari, Mark; Sadeghi, Saman; Keng, Pei Yuin; van Dam, R. Michael. And the article was included in Journal of Pharmaceutical and Biomedical Analysis on June 30,2014.HPLC of Formula: 56632-83-8 The following contents are mentioned in the article:
CE coupled with UV detection was assessed as a possible platform for the chem. identity and purity anal. of positron emission tomog. (PET) tracers using [18F]FAC and [18F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities, as well as real radioactive samples (formulated for injection), were analyzed. Using MEKC with SDS in a neutral phosphate buffer, the separation of all compounds in the samples was achieved with baseline resolutions in less than 4.5 min and 3 min for FLT and FAC samples, resp. In comparison to the gold-standard for chem. anal. (i.e. HPLC/UV), we have demonstrated improvements in anal. times, and comparable LOD. Although the reproducibility in migration time is slightly lower than that of the HPLC, identification of the compounds was still possible due to good peak separation In addition, we show that CE can be used to identify and quantify Krytofix2.2.2 (a toxic and commonly used phase transfer catalyst) in less than 2 min and with a LOD of 45 μg/mL (non-optimized). These results demonstrate adequate performance for chem. identity and purity anal. Combined with the potential for miniaturization into a microchip format, these results suggest the potential of CE as an integral part of a miniaturized quality control system for PET tracers. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8HPLC of Formula: 56632-83-8).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.HPLC of Formula: 56632-83-8
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8