An improved synthesis of 2′-fluoro-2′-deoxyarabinofuranosyl pyrimidine nucleosides was written by Chun, Moon Woo. And the article was included in Archives of Pharmacal Research on June 30,1983.Recommanded Product: 56632-83-8 The following contents are mentioned in the article:
Nucleosides I (R = Ac; R1 = Bz; R2 = H, iodo, Br, F; 64-82% yield) and II (R = Ac; R1 = Bz; R2 = Me, F; yield 51 and 48%) were prepared by treating the corresponding trimethylsilylated bases with 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide and NaI in ClCH2CH2Cl and MeCN for 3 days at room temperature Deacylation with NH3-MeOH gave I and II (R = R1 = H). I and II are potential antiherpes agents. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Recommanded Product: 56632-83-8).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Recommanded Product: 56632-83-8
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