Clauss, Reike team published research on Dalton Transactions in 2022 | 4595-59-9

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., HPLC of Formula: 4595-59-9

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. HPLC of Formula: 4595-59-9.

Clauss, Reike;Baweja, Saral;Gelman, Dmitri;Hey-Hawkins, Evamarie research published 《 Heterobimetallic Pd/Mn and Pd/Co complexes as efficient and stereoselective catalysts for sequential Cu-free Sonogashira coupling-alkyne semi-hydrogenation reactions》, the research content is summarized as follows. A series of heterobimetallic PdII/MII complexes (MII = Mn, Co) was synthesized and tested as precatalysts for sequential Sonogashira coupling-alkyne semi-hydrogenation reactions to form Z-aryl alkenes RCH=CHR1 [R = Ph, 3,4,5-tri-MeOC6H2; R1 = Ph, 4-MeC6H4, 2-thienyl, etc.]. The carbometalated heterobimetallic PdII/CoII complex CoPdL3′ I demonstrated an apparent cooperative effect compared to the corresponding monometallic counterparts. This compound I was identified as a potent single-mol. catalyst for the one-pot Cu-free Sonogashira coupling of aryl bromides with terminal alkynes followed by chemo- and stereoselective semi-hydrogenation of the alkyne intermediate using NH3·BH3 as a hydrogen source. Furthermore, different aromatic substrates had been tested to show the generality of the reaction for the synthesis of Z-alkenes, including biol. active combretastatin A-4. In addition, the homogeneous nature of the catalytically active species was demonstrated.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., HPLC of Formula: 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia