Cleaves, H. James II published the artcile< The Reactions of Nitrogen Heterocycles with Acrolein: Scope and Prebiotic Significance>, Name: 5-Hydroxypyrimidin-4(3H)-one, the main research area is acrolein nucleobase adduct Michael addition prebiotic evolution.
It was suggested that life began with a self-replicating RNA mol. However, after much research into the prebiotic synthesis of RNA, the difficulties encountered have lead some to hypothesize that RNA was preceded by a simpler mol., 1 more easily synthesized prebiotically. Many of the proposed alternative mols. are based on acrolein, since it reacts readily with nucleophiles, such as the nucleobases, via Michael addition and is readily synthesized from formaldehyde and acetaldehyde. Reports regarding the reactions of nucleobases with concentrated acrolein solutions suggest that this is a plausible reaction mechanism, though there are also reports that the “”incorrect”” isomers are obtained. The scope and kinetics of the reaction of acrolein with various nitrogen heterocycles are reported here. Reactions of pyrimidines often give N1 adducts as the major products. Reactions of purines often give N9 adducts in good yield. The reactions are rapid under neutral to slightly alk. conditions, and proceed at low temperatures and dilutions The implications of these findings for the origin of life are discussed.
Astrobiology published new progress about Addition compounds. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Name: 5-Hydroxypyrimidin-4(3H)-one.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia