Reactivity of pyrimidinylphosphazenes with acetylenic esters: Competitive [4 + 2] and [2 + 2] tandem cycloaddition or retro-cycloaddition approaches was written by Cobo, Justo;Molina, Sebastian;Sanchez, Adolfo;Nogueras, Manuel;Insuasty, Braulio;Orozco-Lopez, Fabian. And the article was included in Journal of Heterocyclic Chemistry in 2022.Related Products of 54030-56-7 This article mentions the following:
In the search for new intermediates for heterocyclic synthesis, the reactivity of 6-iminophosphoranepyrimidines against di-Me acetylenedicarboxylate (DMAD) and Et propiolate as dienophiles, was studied. The presence of a viable 2-azadienic moiety in pyrimidin-4-one rings (oxo derivatives) favored reaction of DMAD by [4 + 2]/retro-[4 + 2] sequence, in addition to the expected [2 + 2] cycloaddition/retrocycloaddn. involving phosphazene moiety. In contrast, pyrimidine derivatives lacking a viable 2-azadienic residue reacted only through phosphazene group by the aforementioned [2 + 2]/retro-[2 + 2] tandem process. Et propiolate (nonsym. dienophile) proved less reactive giving rise to undesired side reactions. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Related Products of 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia