Reactivity of 6-aminopyrimidin-4-(3H)-ones towards dimethyl acetylenedicarboxylate (DMAD). Tandem Diels-Alder/retro Diels-Alder (DA/RDA) reaction in the synthesis of 2-aminopyridines was written by Cobo, Justo;Garcia, Celeste;Melguizo, Manuel;Sanchez, Adolfo;Nogueras, Manuel. And the article was included in Tetrahedron in 1994.Reference of 54030-56-7 This article mentions the following:
The reactions of 6-aminopyrimidin-4-(3H)-one derivatives I (R = H, Me; X = O, S) with DMAD were studied. 2-Aminopyridines and 6-amino-5-vinylpyrimidin-4-(3H)-ones were obtained as main products, which can be explained on the basis of DA/RDA reactions, or Michael addition on pyrimidine derivatives In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Reference of 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Reference of 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia