A theoretical investigation on the reactivity of 6-amino-3-methylpyrimidin-4(3H)-ones towards DMAD. Tandem Diels-Alder retro Diels-Alder (DA/RDA) reaction was written by Cobo, Justo;Melguizo, Manuel;Nogueras, Manuel;Sanchez, Adolfo;Dobado, Jose A.;Nonella, Marco. And the article was included in Tetrahedron in 1996.COA of Formula: C6H9N3OS This article mentions the following:
The reactivity of 6-aminopyrimidin-4(3H)-ones towards DMAD is successfully explained by theor. investigation (PM3 semiempirical methods). All the PM3 results (activation energies (AE) for the transition states and the heat of formation (ΔH) for the products) support our previous exptl. work. In those reactions two main products were obtained: the pyridine derivatives as major ones, which are formed by a tandem DA/RDA reaction with extrusion of the Me isocyanate fragment; and 5-ethenylpyrimidin-4(3H)-ones as minor ones, which arose from a Michael addition, being in competition with the above normal DA. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7COA of Formula: C6H9N3OS).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C6H9N3OS
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia