Reactions of 6-aminopyrimidin-4(3H)-ones with electron-deficient alkenyl derivatives. Easy preparation of heterocyclic analogs of sangivamycin was written by Cobo, Justo;Sanchez, Adolfo;Nogueras, Manuel. And the article was included in Tetrahedron in 1998.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:
Aminopyrimidinones I (R = H, Me; X = C(OMe):N, C(SMe):N) and uracils I (R = H, Me; X = CONH, CONMe) react with maleic anhydride to give pyrrolopyrimidines II. I (R = H, Me; X = C(OMe):N, C(SMe):N) undergo Michael addition with maleimide to give stable maleimides III (R = H, Me; X = C(OMe):N, C(SMe):N). I (R = Me, X = C(SMe):N) also undergoes a Diels-Alder reaction with maleimide to give 13% of pyrrolopyrimidine IV. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia