Drug resistant and hypersensitive herpes simplex virus mutants: isolation and application to dissection of the pol locus was written by Coen, Donald M.; Chiou, Henry C.; Fleming, H. Edward Jr.; Leslie, Laurel K.; Retondo, Margaret J.. And the article was included in UCLA Symposia on Molecular and Cellular Biology, New Series in 1984.Category: pyrimidines The following contents are mentioned in the article:
Herpes simplex virus mutants resistant to antiviral drugs and aphidicolin are readily isolated in a single-step selection procedure. However, it was found that mutants resistant to one drug are often not substantially cross-resistant to others suggesting possible solutions to potential clin. resistance. Repeated plaque purification has proven essential for such analyses. Previous studies have identified PAA-, ACG-, and araA-resistance mutations in the DNA polymerase (pol) locus. Mutations conferring hypersensitivity to araA, PAA, FMAU, FIAU, BVdU, 2’NDG, and aphidicolin (Aph) were identified and several of these were mapped to the pol locus. The existence of either type of mutation in the pol locus implies that polymerase is a target for the drugs or otherwise mediates drug-sensitivity. Addnl., cross-resistance patterns of the mutants suggest that polymerases capable of discriminating against one nucleoside analog are incapable of discriminating against closely related compounds Mutations conferring altered sensitivity to the same drug map at different locations in the pol locus. Anal. of these mutations should aid in the functional dissection of the polymerase. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Category: pyrimidines).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Category: pyrimidines
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3