Enzymology and pathogenicity in mice of a herpes simplex virus type 1 mutant resistant to 2′-fluoro-2′-deoxy-1-β-D-arabinofuranosyl-5-iodocytosine was written by Colacino, Joseph; Brownridge, Elizabeth; Greenberg, Nancy; Lopez, Carlos. And the article was included in Antimicrobial Agents and Chemotherapy on May 31,1986.Recommanded Product: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:
The deoxypyrimidine nucleoside analog 2-fluoro-2′-deoxy-1-β-D-arabinofuranosyl-5-iodocytosine (FIAC) [69123-90-6] is a potent and selective inhibitor of herpes simplex virus type I in vitro. Isopycnog. anal. demonstrated that 1 μM FIAC inhibited herpes simplex virus DNA replication by more than 95% but inhibited cellular DNA replication by only 32%. Mutant herpes simplex virus type 1 selected resistant to FIAC displayed linked resistance to other nucleoside analogs, including arabinosylthymine [605-23-2] and acyclovir [59277-89-3]. Lysates derived from Vero cells infected with FIAC-resistant virus showed markedly lower levels of thymidine kinase [9002-06-6] activity and were unable to phosphorylate selectively arabinosylthymine or FIAC, in contrast to lysates from the cells infected with wild-type herpes simplex virus type 1. Drug-resistant virus displayed a 6,000-fold decrease in pathogenicity when inoculated i.p. into genetically susceptible A/J mice. These results indicate that resistance to deoxypyrimidine nucleoside analogs is due, at least in part, to alterations in viral thymidine kinase and is accompanied by decreased pathogenicity in vivo. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Recommanded Product: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
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