On December 31, 2022, Connell, J. R.; Benton, M. C.; Lea, R. A.; Sutherland, H. G.; Chaseling, J.; Haupt, L. M.; Wright, K. M.; Griffiths, L. R. published an article.Product Details of 65-71-4 The title of the article was Pedigree derived mutation rate across the entire mitochondrial genome of the Norfolk Island population. And the article contained the following:
Estimates of mutation rates for various regions of the human mitochondrial genome (mtGenome) vary widely, depending on whether they are inferred using a phylogenetic approach or obtained directly from pedigrees. Traditionally, only the control region, or small portions of the coding region have been targeted for anal. due to the cost and effort required to produce whole mtGenome Sanger profiles. Here, we report one of the first pedigree derived mutation rates for the entire human mtGenome. The entire mtGenome from 225 individuals originating from Norfolk Island was analyzed to estimate the pedigree derived mutation rate and compared against published mutation rates. These individuals were from 45 maternal lineages spanning 345 generational events. Mutation rates for various portions of the mtGenome were calculated Nine mutations (including two transitions and seven cases of heteroplasmy) were observed, resulting in a rate of 0.058 mutations/site/million years (95% CI 0.031-0.108). These mutation rates are approx. 16 times higher than estimates derived from phylogenetic anal. with heteroplasmy detected in 13 samples (n = 225, 5.8% individuals). Providing one of the first pedigree derived estimates for the entire mtGenome, this study provides a better understanding of human mtGenome evolution and has relevance to many research fields, including medicine, anthropol. and forensics. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Product Details of 65-71-4
The Article related to mutation pedigree mitochondrial genome heteroplasmy australia, Mammalian Biochemistry: Classical Genetics and Phylogeny and other aspects.Product Details of 65-71-4
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