Continuously updated synthesis method about 148-51-6

Here is a brief introduction to this compound(148-51-6)Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, if you want to know about other compounds related to this compound(148-51-6), you can read my other articles.

Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1). Author is Wikoff, William R.; Nagle, Megha A.; Kouznetsova, Valentina L.; Tsigelny, Igor F.; Nigam, Sanjay K..

Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of physiol. important metabolites, including several not previously linked to Oat1-mediated transport. Several, such as indoxyl sulfate, derive from Phase II metabolism of enteric gut precursors and accumulate in chronic kidney disease (CKD). Other compounds included vitamins (pantothenic acid, 4-pyridoxic acid), urate, and metabolites in the tryptophan and nucleoside pathways. Three metabolites, indoxyl sulfate, kynurenine, and xanthurenic acid, were elevated in the plasma and interacted strongly and directly with Oat1 in vitro with IC50 of 18, 12, and 50 μM, resp. A pharmacophore model based on several identified Oat1 substrates was used to screen the NCI database and candidate compounds interacting with Oat1 were validated in an in vitro assay. Together, the data suggest a complex, previously unidentified remote communication between the gut microbiome, Phase II metabolism in the liver, and elimination via Oats of the kidney, as well as indicating the importance of Oat1 in the handling of endogenous toxins associated with renal failure and uremia. The possibility that some of the compounds identified may be part of a larger remote sensing and signaling pathway is also discussed.

Here is a brief introduction to this compound(148-51-6)Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, if you want to know about other compounds related to this compound(148-51-6), you can read my other articles.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia