Direct Formic Acid Mediated Z-Selective Reductive Coupling of Dienes and Aldehydes was written by Cooze, Christopher;Dada, Raphael;Lundgren, Rylan J.. And the article was included in Angewandte Chemie, International Edition in 2019.Safety of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:
Demonstrated was that formic acid mediated the Rh-catalyzed, Z-selective coupling of dienes and aldehydes. The processed was distinguished by broad tolerance towards reducible or electrophilic groups. Kinetic anal. suggested that generation of the catalytically active Rh intermediate by ligand dissociation was the rate-determining step. The rapid generation and trapping of Rh-allyl intermediates was key to preventing chain-walking isomerization events that plague related protocols. Insights gained through this study may have wider implications in selective metal-catalyzed hydrofunctionalization reactions. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Safety of 2-Methoxypyrimidine-5-carbaldehyde).
2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Safety of 2-Methoxypyrimidine-5-carbaldehyde
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia