Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis was written by Cousins, David L.;Fricero, Prisca;Kopf, Kenji P. M.;McColl, Elliot J.;Czechtizky, Werngard;Lim, Yee Hwee;Harrity, Joseph P. A.. And the article was included in Angewandte Chemie, International Edition in 2021.Category: pyrimidines This article mentions the following:
We report a novel and general method to access a highly understudied privileged scaffold – pyrimidines bearing a trifluoroborate at C4 (e.g., I) and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chem. is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C-B bond when suitably activated. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Category: pyrimidines).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia