Crich, David; Yao, Qingwei published an article on January 15 ,1998. The article was titled 《Free radical chemistry of nucleosides and nucleotides Ring opening of C4′-radicals》, and you may find the article in Tetrahedron.Related Products of 122567-97-9 The information in the text is summarized as follows:
It is demonstrated that nucleotide C4′ radicals may be generated from a C4′-thioester on treatment with tributyltin hydride. When the reaction is conducted in benzene at reflux the C4′ radical expels the C3′-phosphate group to give a radical cation. This species undergoes deprotonation to an allylic radical which suffers cleavage of the deoxyribose ring. Similar reactions are observed when the reaction is conducted with tris(trimethylsilyl)silane in place of the stannane. In methanolic benzene the radical cation is trapped by methanol to give a new C4′ radical which is quenched before ring opening. The behavior of C4′ radicals toward ring opening is discussed in terms of the conformations imposed by the substituents at C3′. In the experimental materials used by the author, we found ((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9Related Products of 122567-97-9)
((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 122567-97-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia