Cui, Hongyang et al. published their research in Science of the Total Environment in 2021 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Reference of 1220-83-3

Determination and occurrence of sulfonamide transformation products in surface waters was written by Cui, Hongyang;Chang, Hong;Zheng, Hongjin;Wan, Yi. And the article was included in Science of the Total Environment in 2021.Reference of 1220-83-3 This article mentions the following:

The transformation products of sulfonamides (SAs) have raised increasing environmental and health concerns in recent years, but information on their anal. and environmental fates remains limited. In this study, an anal. method using liquid chromatog. with tandem mass spectrometry (LC-MSMS) was optimized to simultaneously analyze 9 SA transformation products and 14 SAs in water samples. This method was applied to investigate the occurrence of antibiotics in three urban rivers in Beijing, and all of the target compounds were detected. N-acetylsulfamethoxazole, N-acetylsulfapyridine, and N-acetylsulfamethazine were found to be the predominant acetyl SAs in the aquatic environment, and high frequencies of hydroxylated SA (5-hydroxysulfapyridine) and glucuronide-conjugated SA (sulfamethoxazole 灏?D-glucuronide) were also detected. The SA transformation products accounted for 22-32% of the total concentrations of SAs and their transformation products in the water samples. The pollution levels of the compounds exerted only minor effects on the proportions of the SA transformation products. The compound-specific transformation of sulfamethoxazole, sulfapyridine, and sulfadiazine in the water samples was consistent with their acetylation efficiencies in metabolic processes in organisms, which suggests that the SA-acetylated products were derived mainly from biol. metabolism in humans or animals. This finding was supported by the fact that environmental degradation exerts a weak effect on SA profiles in the water samples. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia