Easy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes was written by de la Torre, Jose M.;Nogueras, Manuel;Borkowski, Eduardo J.;Suvire, Fernando D.;Enriz, Ricardo D.;Cobo, Justo. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2014.Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:
Pyrimidine-5-carbaldehyde derivatives, of easy access, were selected as precursors for the synthesis of mimic pteridine derivatives 5,6-dihydropyrimido[4,5-d]pyrimidines I [R1 = C6H5, CH2C6H5, C6H11, CH(CH3)C6H5; R2 = H, CH3; X = O, S] and 5,6,7,8- tetrahydropyrimido[4,5-d]pyrimidines II (R3 = H, CH3, C6H5) via 4-amino-(5-aminomethyl)pyrimidine intermediates. Straightforward procedures allow a quick access to these compounds The dihydro derivatives were prepared means of a final cyclocondensation carried out with orthoesters R2R3C(O), catalyzed by acid and assisted by microwaves irradiation under solvent-free conditions. The final cyclocondensation with carbonyl compounds forming the tetrahydro derivatives was done under mild conditions, in which stereochem. induction was carried out on the building of this skeleton, and stereochem. assignments corroborated by theor. calculations In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia