So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yamashita, Junko researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Synthetic Route of C8H12ClNO2.They published the article 《Convulsive seizure induced by intracerebral injection of semicarbazide (an anti-vitamin B6) in the mouse》 about this compound( cas:148-51-6 ) in Journal of Nutritional Science and Vitaminology. Keywords: semicarbazide convulsion; antivitamin B6 convulsion. We’ll tell you more about this compound (cas:148-51-6).
Intracerebral injection of semicarbazide-HCl (I) [563-41-7] was more effective than systemic administration in inducing convulsions and tremors in mice. The symptoms were prevented by pyridoxine [65-23-6], aminooxyacetic acid [645-88-5] and acetone [67-64-1], but were enhanced by pyridoxal [66-72-8], pyridoxal phosphate [54-47-7] and other anti-B6 agents. Smaller doses of I were required for induction of the symptoms in vitamin B6-deficient mice than in controls. I applied to the vicinity of the lambda caused running fits, followed by convulsions and tremors.
After consulting a lot of data, we found that this compound(148-51-6)Synthetic Route of C8H12ClNO2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia