Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 120099-61-8, is researched, Molecular C5H11NO, about Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators, the main research direction is neurotensin receptor 1 allosteric modulator SBI 553 pharmacokinetics.Product Details of 120099-61-8.
Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders but despite extensive efforts to develop small mol. ligands there are few reports of such compounds Herein we describe the optimization of a quinazoline based lead to give 18 (SBI-553(I)), a potent and brain penetrant NTR1 allosteric modulator.
In some applications, this compound(120099-61-8)Product Details of 120099-61-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia