SDS of cas: 148-51-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Preparation of 4-deoxypyridoxine hydrochloride.
The method developed by Wibault et al. (1960) was slightly modified. Thus, nitration of 3-cyano-4,6-dimethyl-2(1H)-pyridone was effected with 65:35 HNO3-Ac2O at 40-5°, whereby explosion hazards were substantially reduced. Thin-layer chromatog. of the 5-nitro derivative on silica gel (Stahl II) with 1:3 MeOH-C6H6 gave Rf 0.73-0.74. In the subsequent chlorination step, the amount of POCl3 was increased and the heating time considerably prolonged to improve the yield of the chlorinated product (Rf 0.76 with 1:3 C5H12-C6H6 on silica gel).
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia