Doherty, Elizabeth M.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2008 | CAS: 659729-09-6

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineOn March 15, 2008, Doherty, Elizabeth M.; Retz, Daniel; Gavva, Narender R.; Tamir, Rami; Treanor, James J. S.; Norman, Mark H. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties》. The article mentions the following:

8-{6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol and its analogs were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility Synthesis, SAR, and improvements in metabolic stability and absorption of these compounds are described. The experimental process involved the reaction of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine)

4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine(cas: 659729-09-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Quality Control of 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia