Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Application In Synthesis of 1722-12-9.
Dutysheva, Elizaveta A.;Utepova, Irina A.;Trestsova, Maria A.;Anisimov, Alexander S.;Charushin, Valery N.;Chupakhin, Oleg N.;Margulis, Boris A.;Guzhova, Irina V.;Lazarev, Vladimir F. research published 《 Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer’s disease》, the research content is summarized as follows. The chems. was able to induce heat shock protein synthesis and therefore rescued neural cells from cytotoxicity associated with amyloid, herein synthesized a group of pyrrolyl- and indolylazines that caused the accumulation of heat shock proteins, using a novel method of photocatalysis that was employed in green chem. The selected compounds were tested in a cell model of Alzheimer’s disease and demonstrated a pronounced neuroprotective effect. These substances increased the survival of neurons, blocked the activation of β-galactosidase and prevented apoptosis in neurons cultured in the presence of β-amyloid.
Application In Synthesis of 1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia