On July 28, 2011, Eidam, Hilary Schneck; Fox, Ryan Michael published a patent.Safety of 5-Phenylpyrimidine-2-carboxylic acid The title of the patent was TRPV4 antagonists as pharmaceutical agents. And the patent contained the following:
The invention discloses indole or benzothiophene analogs I [R1= C1-3 alkyl, C1-3 alkoxy, CF3, halo, etc.; R2= C1-4 alkyl, CH2C3-6 cycloalkyl, CH2Ph; R3= (un)substituted pyrrole, (un)substituted pyridazine, (un)substituted imidazole, (un)substituted indole, etc.; X= bond, CH2; Y= NR4, S; R4= H, C1-3 alkyl; R5= H, C1-5 alkyl; G= (un)substituted heterocycle, (un)substituted cyclopentyl, (un)substituted cyclohexyl, etc.; i= 0,1,2,3], pharmaceutical compositions containing them and their use as TRPV4 antagonists. The experimental process involved the reaction of 5-Phenylpyrimidine-2-carboxylic acid(cas: 85386-20-5).Safety of 5-Phenylpyrimidine-2-carboxylic acid
The Article related to trpv4 antagonist indole benzothiophene derivative pharmaceutical agent, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Safety of 5-Phenylpyrimidine-2-carboxylic acid
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia