El-Ghomari, K. published the artcileMetabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines, Synthetic Route of 74638-76-9, the publication is European Journal of Drug Metabolism and Pharmacokinetics (1987), 12(4), 253-8, database is CAplus and MEDLINE.
Biol. oxidation of 2,4-diamino-6-substituted pyrimidines was studied using hepatic microsomes from various mammalian species. The 3-N-oxides were formed with 6-pipeidino-, 6-diethylamino-, 6-methyl-, and 6-chloro-substituted 2,4-diaminopyrimidines: no evidence of 1-N-oxide formation was obtained. With the 6-hydroxy-, 6-amino-, and unsubstituted 2,4-diaminopyrimidines and melamine, no N-oxidative metabolite was detected. The differences in N-oxide formation is discussed in terms of the effect of substituents on tautomerism and electron distribution. The N-oxygenation was mediated via a cytochrome P 450-dependent system.
European Journal of Drug Metabolism and Pharmacokinetics published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C4H6N4O, Synthetic Route of 74638-76-9.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia