In 2018,El-Kalyoubi, Samar A. published 《Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent》.Chemistry Central Journal published the findings.Related Products of 3764-01-0 The information in the text is summarized as follows:
A series of pyrimido[5,4-e][1,2,4]triazines I (R1 = Ph, 4-ClC6H4, 4-BrC6H4, 4-HOC6H4, 4-O2NC6H4) was obtained via condensation of 6-hydrazinyluracil with various benzaldehydes to give the hydrazones II (R2 = H) followed by nitrosation with HNO2 and intramol. cyclization. On the other hand, pyrazolopyrimidine III (R3 = 1-phenylvinyl) was obtained by the reaction of hydrazone II (R1 = Ph; R2 = Me) with DMF-DMA via formation of the intermediate IV whereas the compound III (R3 = Me) was prepared by refluxing hydrazinyluracil with DMF-DMA in DMF directly. The newly synthesized compounds I, II, III and IV were evaluated in-vitro for their anticancer activity against human lung carcinoma (A549). The compound I (R1 = 4-ClC6H4) showed the highest effect with IC50 value 3.6 μM, followed by compounds III (R3 = 1-phenylvinyl), II (R1 = R2 = H), IV, II (R1 = 4-O2NC6H4; R2 = H) and I (R1 = 4-O2NC6H4). After reading the article, we found that the author used 2,4,6-Trichloropyrimidine(cas: 3764-01-0Related Products of 3764-01-0)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Related Products of 3764-01-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia