Ultrasound-assisted microwave synthesis and mechanistic aspect of 2-amino-4, 6-diaryl pyrimidines and 3, 5-diaryl-1H- pyrazoles was written by Elzupir, Amin O.;Saeed, Ahmed E. M.;Barakat, Izzeldeen E.;Van Der Westhuizen, Jan H.. And the article was included in International Journal of Current Pharmaceutical Research in 2015.COA of Formula: C16H13N3 This article mentions the following:
A novel approach was developed for synthesis of a series of 2-amino-4,6-diaryl pyrimidines and 3,5-diaryl-1H-pyrazoles, using a condensation reaction of guanidine or hydrazine with enones compounds, in the presence of ethanol as solvent and NaOAc as catalyst. Ultrasound was used for solvation of the enones, followed by microwave for heterocyclization reaction. A moderate to good yield was gotten in a short period of time. The structures of synthetic compounds were elucidated by 1H NMR, EI-MS, FT-IR and UV-Vis spectroscopy. Moreover, the mechanism of reaction was investigated; the products were formed through direct addition to hard electrophile followed by heterocyclization. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.COA of Formula: C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia