Extended knowledge of 1195-08-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1195-08-0, 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1195-08-0 ,Some common heterocyclic compound, 1195-08-0, molecular formula is C5H4N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Amine 2.2; 5-[(cyclopropylamino)methyl]-l ,3-bis(3-methoxypropyl)pyrimidine-2,4(lH,3/i)- dione; Step 1 : l,3-bis(3-methoxypropyl)-2,4-dioxo-l,2,3,4-tetrahvdropyrimidine-5-carbaldehvde; To a solution of 2,4-dioxo-l,2,3,4-tetrahydropyrimidine-5-carbaldehyde (1 eq.) and l-bromo-3-methoxypropane (2.2 eq.) at rt in DMF (0.36 M) was added DBU (2.2 eq.). The reaction mixture was stirred at rt 3 days, concentrated in vacuo, and the residue purified by flash chromatography (SiO2; EtOAc) to afford the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1195-08-0, 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/70869; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia