Adding a certain compound to certain chemical reactions, such as: 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1197953-49-3, blongs to pyrimidines compound. Product Details of 1197953-49-3
General procedure: To asolution of (2-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide (3f) (0.1 g, 0.334 mmol) and 4-fluoro-2-methoxy-5-nitroaniline (0.124 g, 0.667 mmol) in sec-butanol(2 mL) was added potassium carbonate (0.231 g, 1.669 mmol). Thereaction mixturewas stirred at 80 C for 10 min and then Pd2 (dba)3(0.031 g, 0.033 mmol) and Xphos (0.016 g, 0.033 mmol) were addedrapidly. The reaction mixture was stirred at 100 C for 2 h. Aftercompletion of the reaction, the resulting mixture was hot-filteredthrough Celite and washed with DCM. The filtrate was concentratedunder reduced pressure and then purified by flash columnchromatography on silica gel (0-20% MeOH in DCM) to afford 4f asa yellowish solid (0.128 g, 85%).
The synthetic route of 1197953-49-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jang, Jaebong; Son, Jung Beom; To, Ciric; Bahcall, Magda; Kim, So Young; Kang, Seock Yong; Mushajiang, Mierzhati; Lee, Younho; Jaenne, Pasi A.; Choi, Hwan Geun; Gray, Nathanael S.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 497 – 510;,
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