As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 137281-08-4, name is N-(4-Oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide, molecular formula is C11H14N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 137281-08-4
N-Methyl benzylamine (3.63 g, 30 mmol) and paraformaldehyde(1.05 g, 35 mmol) were added to water (20 mL). To this solution, aceticacid (20 mL) was added dropwise. The mixture was stirred at 80 C for3 h. Compound 21 (2.34 g, 10 mmol) and KOAc (2.94 g, 30 mmol) wereadded and the stirring was continued at 80 C overnight. The solventwas removed by a rotary evaporator and acetone (40 mL) was added.The suspension was filtered and the filtrate was concentrated into asemisolid residue. This residue was purified by a silica column, whichwas flushed with CHCl3 and MeOH, to provide 2.86 g of a white solid,22, in 78% yield. mp: 181.1-182.5 C; TLC Rf 0.37 (CHCl3: MeOH,20:1); 1H NMR (DMSO-d6) delta 1.24 (s, 9H, Piv), 2.09 (s, 3H, NCH3), 3.48(s, 2H, NCH2), 3.58 (s, 2H, NCH2), 6.31 (s, 1H, 5-H), 7.32 (m, 5H, Ph),10.85 (br, 1H, exch, PivNH), 11.55 (br, 1H, exch, NH), 11.95 (br, 1H,exch, NH); Anal. calcd. for (C20H25N5O2·0.5H2O) C, H, N; UPLCMS> 95%; m/z [M-MePhNH]+, calcd 247.12, found 247.25.
With the rapid development of chemical substances, we look forward to future research findings about 137281-08-4.
Reference:
Article; Xiang, Weiguo; Dekhne, Aamod; Doshi, Arpit; O’Connor, Carrie; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry; vol. 27; 23; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia