Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14001-67-3, name is 5-Bromo-2-methylthiopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 5-Bromo-2-methylthiopyrimidine
A mixture of azetidine (0.03 mL, 0.5 mmol), 5-bromo-2-(methylthio)pyrimidine (100 mg, 0.49 mmol),Xantphos (4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene) (9.9 mg, 0.02 mmol), Pd(OAc)2 (2 mg, 0.01 mmol) and NaOt-Bu (140 mg, 1 .5 mmol) in toluene (1 .7 mL) was heated at 110C. After 3h, the reaction mixture was cooled to room temperature and concentrated under vacuum. Purification (FCC, 5i02, 0-99% EtOAc in hexanes) afforded the title compound (39 mg,44%). MS(ESl): mass calcd. forC8H11N3S, 181.1; m/zfound, 182.1 [M+H]. 1H NMR (400 MHz, DMSO-d5) O 7.96 (s, 2H), 3.87 (t, J = 7.3 Hz, 4H), 2.45 (s, 3H), 2.40 -2.32 (m, 2H).
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Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHEN, Gang; CHROVIAN, Christa C.; COATE, Heather R.; DVORAK, Curt A.; GELIN, Christine F.; HISCOX, Afton; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; STENNE, Brice; WALL, Jessica L.; ZHANG, Wei; (583 pag.)WO2017/139428; (2017); A1;,
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